Anti-Collagen [M2139]

Description:

Recombinant monoclonal antibody to Collagen. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma M2139.

Clone Name:

M2139

Published Application(s):

FN, Block, ELISA, IHC, IHC-Fr

Published Species Reactivity:

Mouse, Human, Rat, Bovine, Chicken

Products based on this clone:

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Ab00466-1.1 Anti-Collagen [M2139]
Mouse, Human, Rat, Bovine, Chicken
Mouse IgG1
Purified
In Stock

Ab00466-23.0 Anti-Collagen [M2139]
Mouse, Human, Rat, Bovine, Chicken
Rabbit IgG
Purified
In Stock

UniProt Accession Number of Target Protein: P02458

Alternative Name(s) of Target: CollA;Collagen alpha-1 (II) chain; Alpha-1 type II collagen
Immunogen: Rat CII.

Application Notes: The antibody binds specifically to the J1 epitope of Type II collagen, necessary to provide tensile strength to tissues. The antibody is extremely arthritogenic, and can induce the disease in mice following a single transfer.

Antibody first published in: Raposo et al. Epitope-specific antibody response is controlled by immunoglobulin VH polymorphisms. J. Exp. Med. 211 (3), 405-411 (2014) PMID:24534192
Note on publication: Describes the role of autoantibodies to Type II collagen (CII) in the development of rheumatoid arthritis (RA). Also describes the utilisation of the anti-CII monoclonal antibody M2139 to induce arthritis in mice, in order to highlight their role in the autoimmune disease.