Anti-desmoglein-3 [PVA218]

Description:

Recombinant monoclonal antibody to desmoglein-3. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the EBV transformed human B cell clone PVA218.

Made with Antibody Sequences licensed from Humabs Biomed SA.

Clone Name:

PVA218

Published Application(s):

ELISA, IF

Published Species Reactivity:

Human

Products based on this clone:

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Ab00157-1.1 Anti-desmoglein-3 [PVA218]
Human
Mouse IgG1
Purified
In Stock

Ab00157-13.0 Anti-desmoglein-3 [PVA218]
Human
Human IgG4
Purified
Ships in 4-5 weeks

UniProt Accession Number of Target Protein: P32926

Alternative Name(s) of Target: Pemphigus Vulgaris Ag; 130 kDa pemphigus vulgaris antigen; PVA; Cadherin family member 6; DSG3; CDHF6
Immunogen: Made by immortalizing IgG-expressing B cells from Pemphigus vulgaris (PV) patients.

Specificity: This antibody specifically recognizes a conformational epitope in the EC3 domain of human desmoglein-3 (DSG This antibody was isolated as a human IgG4 from a patient with mucocutaneous pemphigus vulgaris and uses the VH5a*03, D6-6*01, JH3*01, VL1-33*01and JL2*01. This antibody does not have in vitro and in vivo pathogenic activity, as assessed in a keratinocyte dissociation assay and by the formation of microscopic blisters in newborn mice.

Antibody first published in: Di Zenzo, G. et al. Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface. J Clin Invest 122, 3781–3790 (2012). PMID:22996451
Note on publication: Describes the isolation and analysis of a panel of human antibodies from patients - inc data on ELISA, IF and in vitro and in vivo pathogenic activity assays.

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