Anti-DM1 [06CT8.1.1.1]

Name: Anti-DM1 [06CT8.1.1.1]
SKU: Ab04093
Availability: InStock

Description:

Recombinant monoclonal antibody to DM1. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 06CT8.1.1.1.

Clone Name:

06CT8.1.1.1

Published Application(s):

ELISA

Published Species Reactivity:

Species independent

Products based on this clone:

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Please Select

Ab04093-10.3 Anti-DM1 [06CT8.1.1.1]
Species independent
Human IgG1
Fc Silent™
Purified
Ships in 5-6 weeks

Ab04093-10.0 Anti-DM1 [06CT8.1.1.1]
Species independent
Human IgG1
Purified
Ships in 5-6 weeks

Ab04093-1.1 Anti-DM1 [06CT8.1.1.1]
Species independent
Mouse IgG1
Purified
Ships in 5-6 weeks

Ab04093-23.0 Anti-DM1 [06CT8.1.1.1]
Species independent
Rabbit IgG
Purified
Ships in 5-6 weeks

Alternative Name(s) of Target: Mertansine; Maytansinoid
Immunogen: The original antibody was generated by immunizing BALB/c mice with DM1-cysteine-KLH conjugate.

Specificity: This antibody binds maytansine (DM1), a thiol-containing maytansinoid which is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations. The potent cell killing ability of maytansine can be used in a targeted delivery approach, such as an antibody-drug conjugate (ADC), for the selective delivery of the drug and destruction of cancer cells. ADCs with this design include trastuzumab emtansine, lorvotuzumab mertansine, and cantuzumab mertansine.

Application Notes: The binding reactivity of this antibody towards BSA-DM1 was determined using ELISA. This antibody is recommended for detection of antibody-drug conjugates containing DM1 (CN114276448).

Antibody first published in: PMID: