Anti-DR4 [T1014G03 ]

Description:

Recombinant monoclonal antibody to DR4. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the human B cell clone T1014G03 .

Clone Name:

T1014G03

Published Application(s):

in vivo, ELISA

Published Species Reactivity:

Human

Products based on this clone:

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Ab04096-10.3 Anti-DR4 [T1014G03 ]
Human
Human IgG1
Fc Silent™
Purified
Ships in 5-6 weeks

Ab04096-10.0 Anti-DR4 [T1014G03 ]
Human
Human IgG1
Purified
Ships in 5-6 weeks

Ab04096-3.0 Anti-DR4 [T1014G03 ]
Human
Mouse IgG2b
Purified
Ships in 5-6 weeks

Ab04096-3.3 Anti-DR4 [T1014G03 ]
Human
Mouse IgG2b
Fc Silent™
Purified
Ships in 5-6 weeks

Ab04096-23.0 Anti-DR4 [T1014G03 ]
Human
Rabbit IgG
Purified
Ships in 5-6 weeks

UniProt Accession Number of Target Protein: O00220

Alternative Name(s) of Target: CD261; TR4; TNFRSF10A; APO2; TRAILR1; Tumor necrosis factor receptor superfamily member 10A; Death receptor 4; TNF-related apoptosis-inducing ligand receptor 1
Immunogen: The original antibody was isolated from a human scFv library by panning against human TR4 fusion protein. Later on the scFv version of this antibody was converted to human IgG1 version for carrying out further studies.

Specificity: This antibody binds human CD261 (TR4 or TRAILR1 or TNFRSF10A). This protein acts as a receptor for the cytotoxic ligand TNFSF10/TRAIL and transduces cell death signal and induces cell apoptosis.

Application Notes: The binding specificity of this antibody to human TR4 (CD126) fusion protein was determined using ELISA. This antibody does not cross react with other proteins like TR7, TR5, TR10 and BLyS. It was reported that the scFv version of the antibody binds human TR4 fusion protein with a binding affinity of Kd= 5.54 × 10^(-10) nM. It was also reported that when administered with in vivo Topotecan, this antibody was capable of retarding the growth of tumor cells in nude mice (US7064189).

Antibody first published in: PMID: