- Ab00458-1.1 Anti-dsRNA [9D5 ]
- Mouse IgG1
- In Stock
- Ab00458-23.0 Anti-dsRNA [9D5 ]
- Rabbit IgG
- In Stock
Recombinant monoclonal antibody to dsRNA. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 9D5 .
Alternative Name(s) of Target: double-stranded RNA; double-stranded ribonucleic acid
Immunogen: RDV-RNA-methylated bovine serum albumin complex.
Application Notes: The antibody binds specifically to ds-RNA, which is part of the genetic material of some viruses, such as rotaviruses and the bluetongue virus. The antibody can be used as a diagnostic tool, to determine the nature of an unknown pathogen, and could potentially be used in gene therapy.
Antibody first published in:
Kitagawa et al. Immunogenicity of rice dwarf virus-ribonucleic acid. Tohoku J. Exp. Med. 122 (4), 337-343 (1977) PMID:918970
Note on publication: Describes the production and characterisation of antibodies against double-stranded RNA found in the rice dwarf virus (RDV). the antibodies are produced in rabbits immunized with anti-RDV-RNA-methylated bovine serum albumin complexes.
Immunofluorescence staining of cells infected with a Dengue 2 virus using anti-dsRNA antibody (Ab00458) 9D5. Immunofluorescence analysis of Triton-permeabilised paraformaldehyde-fixed cells stained with the chimeric rabbit version of 1D3 (Ab00458-23.0) at 3.3 µg/ml followed by Alexa Fluor® 568 secondary antibody, showing dsRNA staining. The nuclear stain is DAPI (blue). Images are kind courtesy of Cecilia Alejandra Vazquez (IQUIBICEN (UBA-CONICET)).