Anti-E-selectin [CY1787]

Name: Anti-E-selectin [CY1787]
SKU: Ab02668
Availability: InStock

Description:

Recombinant monoclonal antibody to E-selectin. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma CY1787.

Clone Name:

CY1787

Published Application(s):

functional assay, therapeutical, ELISA, IHC

Published Species Reactivity:

Human

Products based on this clone:

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Ab02668-5.0 Anti-E-selectin [CY1787]
Human
Mouse IgG3
Purified
Ships in 5-6 weeks

Ab02668-5.3 Anti-E-selectin [CY1787]
Human
Mouse IgG3
Fc Silent™
Purified
Ships in 5-6 weeks

Ab02668-10.0 Anti-E-selectin [CY1787]
Human
Human IgG1
Purified
Ships in 5-6 weeks

Ab02668-10.3 Anti-E-selectin [CY1787]
Human
Human IgG1
Fc Silent™
Purified
Ships in 5-6 weeks

Ab02668-23.0 Anti-E-selectin [CY1787]
Human
Rabbit IgG
Purified
Ships in 5-6 weeks

Alternative Name(s) of Target: SELE; CD62 antigen-like family member E; Endothelial leukocyte adhesion molecule 1; ELAM-1; Leukocyte-endothelial cell adhesion molecule 2; LECAM2; CD62E
Immunogen: The original mouse version of this antibody was raised by immunizing a mouse with E-selectin.

Specificity: This antibody is specific for human E-selectin. E-selectin is a cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis.

Application Notes: To test whether the recombinantly created e-selectin was expressed ELISA was preformed with the murine version of this antibody (WO1996040942A1). To test the binding specificity of the human version of this antibody an ELISA was preformed on soluble e-selectin (WO1996040942A1). Neutrophil adhesion to activated ECs under rotating conditions was assayed in the presence of the murine version of this antibody. Neutrophil adhesion to stimulated ECs under rotating conditions was completely inhibited by this antibody (Matsumiya et al, 1999; pmid:10069494). To determine the saferty and pharmokinetics of the murine version of this antibody in patients with newly developed septic shock. This antibody was given to nine patients that survived the first 24 hours of septic shock. This antibody was well tolerated in all patients. Signs of shock resolved in all patients, and organ failure entirely reversed in eight patients (Friedmann et al, 1996; pmid:8605793). To study e-selectin expression in a feline model of myocardial ischemia and reperfusion. The murine version of this antibody was used for immunohistochemistry on the heart and coronary arteries of male cats. (Weyrich et al, 1995; pmid:7530283).

Antibody first published in: Weyrich et al. Time course of coronary vascular endothelial adhesion molecule expression during reperfusion of the ischemic feline myocardium J Leukoc Biol. 1995 Jan;57(1):45-55. PMID:7530283
Note on publication: The time course of endothelial P-selectin, ICAM-1, and E-selectin expression was studied in a feline model of myocardial ischemia and reperfusion.