Anti-Ferritin [F11 (HSF102)]

Description:

Recombinant monoclonal antibody to Ferritin. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma F11 (HSF102).

Clone Name:

F11 (HSF102)

Published Application(s):

ELISA

Published Species Reactivity:

Human

Products based on this clone:

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Ab03943-10.3 Anti-Ferritin [F11 (HSF102)]
Human
Human IgG1
Fc Silent™
Purified
Ships in 5-6 weeks

Ab03943-10.0 Anti-Ferritin [F11 (HSF102)]
Human
Human IgG1
Purified
Ships in 5-6 weeks

Ab03943-23.0 Anti-Ferritin [F11 (HSF102)]
Human
Rabbit IgG
Purified
Ships in 5-6 weeks

Ab03943-2.0 Anti-Ferritin [F11 (HSF102)]
Human
Mouse IgG2a
Purified
Ships in 5-6 weeks

Ab03943-2.3 Anti-Ferritin [F11 (HSF102)]
Human
Mouse IgG2a
Fc Silent™
Purified
Ships in 5-6 weeks

UniProt Accession Number of Target Protein: Q8N4E7

Alternative Name(s) of Target: FTMT; FTL; FTH1; Ferritin mitochondrial; B8
Immunogen: The original antibody was generated by immunizing female Balb/c mice with ferritin extracted from human spleen cells.

Specificity: This antibody binds human ferritin. This protein catalyzes the oxidation of ferrous iron(II) to ferric iron(III) and stores iron in a soluble, non-toxic, readily available form. Ferritin is important for iron homeostasis.

Application Notes: The binding characterization of this antibody towards human spleen ferritin was done using ELISA. This antibody was also reported to show binding affinity for protein A. Binding of this antibody to ferritin causes antigen-induced conformational changes in the antibody and reduces its affinity for protein A (PMID: 9776583).

Antibody first published in: Bespalov et al. Preparation of single-chained antibodies to human ferritin in Escherichia coli. Mol Biol (Mosk). 1993 Mar-Apr;27(2):451-60. PMID:8487773
Note on publication: Describes the generation of scFv antibodies using E. coli expression system.