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- Ab00979-1.1 Anti-GluCl [GluCl]
- C. elegans
- Mouse IgG1
- Purified
- In Stock
- Ab00979-23.0 Anti-GluCl [GluCl]
- C. elegans
- Rabbit IgG
- Purified
- Ships in 4-5 weeks
Recombinant monoclonal antibody to GluCl. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma GluCl.
UniProt Accession Number of Target Protein: G5EBR3
Alternative Name(s) of Target: Glutamate-gated chloride channel
Immunogen: The antibody was raised against GluCl using standard methods.
Specificity: The antibody is specific for C. elegans GluCl. Customers report no detection of Drosophila GluCl by IHC.
Application Notes: The specificity of the antibody for properly folded pentameric GluCl has been assayed in Western blot and FSEC. A Fab fragment of this antibody was used to determine the structure of C. elegans GluCl by X-ray crystallography. Binding of the Fab to GluCl does not affect glutamate- or ivermectin-induced activity.
Antibody first published in:
Hibbs et al. Principles of activation and permeation in an anion-selective Cys-loop receptor. Nature. 2011 Jun 2;474(7349):54-60 PMID:21572436
Note on publication:
Describes the crystallisation of GluCl in complex with ivermectin and Fab.