Anti-Glycoprotein Ilb/IIIa [SE]

Name: Anti-Glycoprotein Ilb/IIIa [SE]
SKU: Ab03507
Availability: InStock

Description:

Recombinant monoclonal antibody to Glycoprotein Ilb/IIIa. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody SE.

Clone Name:

Published Application(s):

Published Species Reactivity:

Human

Products based on this clone:

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Ab03507-23.0 Anti-Glycoprotein Ilb/IIIa [SE]
Human
Rabbit IgG
Purified
Ships in 5-6 weeks

Ab03507-30.11 Anti-Glycoprotein Ilb/IIIa [SE]
Human
scFv fragment (His)
ScFv
Purified
Ships in 5-6 weeks

Ab03507-10.3 Anti-Glycoprotein Ilb/IIIa [SE]
Human
Human IgG1
Fc Silent™
Purified
Ships in 5-6 weeks

Ab03507-10.0 Anti-Glycoprotein Ilb/IIIa [SE]
Human
Human IgG1
Purified
Ships in 5-6 weeks

UniProt Accession Number of Target Protein: P08514

Alternative Name(s) of Target: GPIIb/IIIa; CD41/CD61; integrin allb83
Immunogen: The original antibody was generated by screening human scFv antibody libraries.

Specificity: This antibody binds the glycoprotein GPIIb/IIIa complex (CD41/CD61 complex). The GPIIb/IIIa is a heterodimeric complex formed after synthesis of one lib and one Ilia subunit. The principal ligand for GPIIb/IIIa is fibrinogen, but it also binds to fibronectin, von Willebrand factor, vitronectin, thrombospondin and CD40 ligand. The binding between GPIIb/IIIa and fibrinogen dimers leads to platelet aggregation and thrombus formation, and this is possible only when the receptor adopts its activated conformation.

Application Notes: The antibody bound to activated platelets and inhibited platelet activation. This antibody was used for detection of activated platelets by flow cytometry (WO2020237304).

Antibody first published in: PMID:

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