United Kingdom (UK)
Recombinant monoclonal antibody to high MWT epithelial antigens. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma KC4G3.
Alternative Name(s) of Target: High molecular weight epithelial antigen
Immunogen: This antibody was raised by immunising mice with human prostatic cancer cells.
Specificity: This antibody recognizes high molecular weight antigens in epithelial cells, both on the cell membrane and in the cytoplasm, and reacts with the majority of human epithelial cancers.
Application Notes: This antibody has beeen recommended for the detection and visualisation of various carcinomas. For instance, it was used to stain human breast carcinoma tissue (Hofheinz et al., 1987). KC4G3 antibody was also utilised in the imaging of mammary adenocarcinomas in mice and might be used in the analysis and potentsilly therapy of epithelial maligancies (Couto et al., 1993; Longley et al., 1990).
Antibody first published in:
Hofheinz et al. Monoclonal antibody, KC4G3, recognizes a novel widely expressed antigen on human epithelial cancers. PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH (Vol. 28, pp. 391-391). 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA: AMER ASSOC CANCER RESEARCH. PMID:
Note on publication:
This article describes the generation and characterisation of the KC4G3 antibody.