United Kingdom (UK)
Recombinant monoclonal antibody to Infectious bronchitis virus. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the chicken B cell clone ZL.80.
Alternative Name(s) of Target: IBV; M41 strain
Immunogen: The original antibody was isolated from an immunized chicken library using phage display technology.
Specificity: This antibody binds the infectious bronchitis virus.
Application Notes: The screening of this antibody for binding infectious bronchitis virus was done using indirect ELISA. This antibody is an affinity matured version of the original parent ZL.80 derived by a point mutation in the heavy chain variable region by substituting ValH108Tyr (Lin et al., 2011).
Antibody first published in:
Lin et al. Improved affinity of a chicken single-chain antibody to avian infectious bronchitis virus by site-directed mutagenesis of complementarity-determining region H3. African Journal of Biotechnology (2011); Vol. 10(79); pp. 18294-18302. PMID:
Note on publication:
Describes the generation of an affinity matured version of this antibody using site directed mutagenesis.