Anti-Influenza A HA [HA]

Name: Anti-Influenza A HA [HA]
SKU: Ab00151

Description:

Recombinant monoclonal antibody to Influenza A HA. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the EBV transformed human B cell clone HA.

Clone Name:

Published Application(s):

ELISA

Published Species Reactivity:

Influenza A Virus (several subtypes)

Products based on this clone:

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Ab00151-10.0 Anti-Influenza A HA [HA]
Influenza A Virus (several subtypes)
Human IgG1
Purified
In Stock

Ab00151-1.1 Anti-Influenza A HA [HA]
Influenza A Virus (several subtypes)
Mouse IgG1
Purified
In Stock

Alternative Name(s) of Target: haemagglutinin; hemagglutinin
Immunogen: Made by immortalizing IgG-expressing B cells from individuals following vaccination with seasonal influenza vaccine, containing H1 and H3 influenza Virus subtypes.

Specificity: This antibody specifically recognizes the conformational epitope in the stem region of HA in which amino acid sequences are highly conserved in H1N1, H5N1, H6N1, and H9N2 subtypes of Influenza A viru This antibody uses the VH1-69*01, D3-10*01, JH5*02, VL2D-29*02 and JL4. This antibody does not cross react with HA in H2N2, H3N2 and H7N7 subtype of Influenza A Virus. This antibody has no effect on haemagglutination-inhibition activity.

Antibody first published in: Corti, D. et al. Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine. J Clin Invest 120, 1663–1673 (2010). PMID:20389023
Note on publication: Describes the isolation and analysis of a panel of human antibodies from vaccinated individuals and its evaluation using Virus neutralization assays.