United Kingdom (UK)
Recombinant monoclonal antibody to LAG-3. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 22G3.
UniProt Accession Number of Target Protein: P18627
Alternative Name(s) of Target: CD223; LAG3; Lymphocyte-activation gene-3; Lymphocyte activation gene 3 protein; LAG-3; CGMCNO 20774
Immunogen: The original antibody was generated by immunizing mice with recombinant LAG3 protein.
Specificity: The antibody is specific for LAG3. Lymphocyte activation gene 3 protein is an inhibitory receptor on antigen activated T-cells. It delivers inhibitory signals upon binding to ligands, such as FGL1.
Application Notes: The antibody specifically detected LAG3 protein in Western blot analysis. The antibody and the commercial antibody EPR20261 were used to stain tonsillar granulocytes and granulocytes in the appendix. Results showed the antibody specificity is comparable to the commercial antibody. Further, the sensitivity of the antibody 22G3 was higher than the commercial antibody. The antibody and the commercially available antibody E3 were simultaneously detected on the normal tissue chip, indicating that the specificity of the antibody in normal tissue was equivalent to that of the commercially available antibody (CN113234159A).
Antibody first published in: PMID: