Anti-LgR5 [1-12]

Name: Anti-LgR5 [1-12]
SKU: Ab04170
Availability: InStock

Description:

Recombinant monoclonal antibody to LgR5. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 1-12.

Clone Name:

1-12

Published Application(s):

FACS, ELISA, IHC

Published Species Reactivity:

Human

Products based on this clone:

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Ab04170-11.0 Anti-LgR5 [1-12]
Human
Human IgG2
Purified
Ships in 5-6 weeks

Ab04170-23.0 Anti-LgR5 [1-12]
Human
Rabbit IgG
Purified
Ships in 5-6 weeks

UniProt Accession Number of Target Protein: O75473

Alternative Name(s) of Target: LGR5.1-12; Leucine-rich repeat-containing G-protein coupled receptor 5; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38
Immunogen: The original antibody was originated by immunizing rabbits with an LgR5 extracellular domain (ECD) huFc.

Specificity: The antibody is specific for human LgR5. The antibody binds an epitope outside the region of amino acids 22 to 322 of human LgR5.

Application Notes: The specificity of the original format of the antibody was confirmed by ELISA analysis. The original format of the antibody could recognise human LgR5 expressed in 293 cells by FACS. The original format of the antibody was used to detect expression of LgR5 on normal human tissues by immunohistochemistry. The antibody stained normal intestinal crypts in the expected pattern. The antibody also showed moderate staining in hair follicle, and weak staining in fallopian tube, endometrium, adrenal gland, and spinal cord. Further, the antibody detected LgR5 in different colon cancer cell lines (SW403, SW948, CACO-2, T84, KM-12, C2BBel, SW1463, SK-CO-1, LOVO) by immunohistochemistry (US20190248889).

Antibody first published in: PMID: