- Ab00695-1.1 Anti-MERS-CoV Spike Protein [4c2]
- Mouse IgG1
- In Stock
- Ab00695-23.0 Anti-MERS-CoV Spike Protein [4c2]
- Rabbit IgG
- In Stock
Recombinant monoclonal antibody to MERS-CoV Spike Protein. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 4c2.
Alternative Name(s) of Target: MERS-RBD; Middle East respiratory syndrome coronavirus spike
Immunogen: Recombinant spike receptor-binding domain of MERS-CoV prepared from insect High5 cells.
Specificity: This antibody binds MERS-CoV spike protein at an epitope overlapping with the receptor-binding domain (MERS-RBD).
Application Notes: This antibody binds to MERS-RBD and blocks virus entry in vitro with high efficacy by both steric hindrance and interface-residue competition.
Antibody first published in:
Li et al. A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein Cell Research 25, 1237-1249 PMID:26391698
Note on publication: Describes the generation as well as functional and structural characterization of this antibody.