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- Ab03811-30.11 Anti-MerTK [Ab2000]
- Human
- scFv fragment (His)
- ScFv
- Purified
- Ships in 5-6 weeks
- Ab03811-23.0 Anti-MerTK [Ab2000]
- Human
- Rabbit IgG
- Purified
- Ships in 5-6 weeks
Recombinant monoclonal antibody to MerTK. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody Ab2000.
UniProt Accession Number of Target Protein: Q12866
Alternative Name(s) of Target: Tyrosine-protein kinase Mer; EC:2.7.10.1; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK
Immunogen: The original antibody was generated by phage display method. A phage display library was screened against the extracellular domain of human and/or mouse MerTK.
Specificity: The antibody specifically binds to human MerTK.
Application Notes: The specificity of the IgG1 format of the antibody was confirmed by ELISA analysis. The antibody bound to cellularly expressed full length human MerTK in a dose responsive manner, with EC50 values in the picomolar to nanomolar range, as determined by FACS. The antibody inhibited Gas6 binding to hMerTK in a dose responsive manner, with an IC50 of 1 nM (WO2019084307A1).
Antibody first published in: PMID: