United Kingdom (UK)
Recombinant monoclonal antibody to Bcl-3. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma ham150-3.5.
UniProt Accession Number of Target Protein: Q9Z2F6
Alternative Name(s) of Target: B-cell lymphoma 3 protein homolog
Immunogen: The original antibody was generated from a hamster immunized with mouse BCL-3.
Specificity: The antibody is specific for BCL-3. B cell Lymphoma 3 is a member of the IkB subfamily of inhibitors. This subfamily is part of the NF-kB transcription factor protein family and it is suggested that a balance in the concentration of various NF-kB family members regulates apoptosis and survival of activated T cells.
Application Notes: The specificity of the original format of the antibody for mBcl-3 was confirmed by ELISA analysis. The antibody detected mBcl-3 and human Bcl-3 by western blot (Bassetti et al., 2009; PMID: 19208752).
Antibody first published in:
Bassetti et al. Transgenic Bcl-3 slows T cell proliferation. Int Immunol. 2009 Apr; 21(4): 339–348. PMID:19208752
Note on publication:
The original paper describes the generation and characterization of the antibody.