Anti-NS1 [22NS1 ]

Description:

Recombinant monoclonal antibody to NS1. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 22NS1 .

Clone Name:

22NS1

Published Application(s):

crystallography, NTRL, FC

Published Species Reactivity:

West Nile Virus

Products based on this clone:

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Ab00675-2.0 Anti-NS1 [22NS1 ]
West Nile Virus
Mouse IgG2a
Purified
In Stock

Ab00675-23.0 Anti-NS1 [22NS1 ]
West Nile Virus
Rabbit IgG
Purified
In Stock

Alternative Name(s) of Target: Flavivirus nonstructural protein 1; WNV NS1
Immunogen: A recombinant, secreted form of West Nile virus (WNV) NS1 glycoprotein from baculovirus-infected insect cells.

Specificity: This antibody binds to the NS1 protein (aa 158 to 352) of WNV lineage I (New York strain 3000.0259) and lineage II WNV (956). No reactivity to Dengue virus-2 (16681) was observed.

Application Notes: This antibody binds the NS1 protein and has a protective function in a C57BL/6 mouse-model . NS1 binds several complement proteins (C1q, C1s, and C4) and regulators (factor H, C4 binding protein, and clusterin)and antagonizes their functions

Antibody first published in: Chung et al. Antibodies against West Nile Virus Nonstructural Protein NS1 Prevent Lethal Infection through Fc γ Receptor-Dependent and -Independent Mechanisms J Virol. 2006 Feb; 80(3): 1340–1351 PMID:16415011
Note on publication: Describes the generation and characterization of protection of this antibody.

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