Anti-Nucleoprotein [1307]

Description:

Recombinant monoclonal antibody to Nucleoprotein. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the alpaca peripheral blood lymphocytes 1307.

Clone Name:

1307

Published Application(s):

Published Species Reactivity:

Vesicular stomatitis virus (VSV)

UniProt Accession Number of Target Protein: P03521

Alternative Name(s) of Target: NP; Nucleocapsid protein; Protein N; VHH 1004; Nb1004
Immunogen: The original antibody was generated by immunized two alpaca with inactivated vesicular stomatitis virus (VSV).

Specificity: This antibody binds the nucleoprotein of the vesicular stomatitis virus (VSV), a zoonotic arbovirus that belongs to the family, Rhabdoviridae. VSV transmission in animals occurs through insect bites, and can cause severe disease in cattle, horses, and swine with symptoms similar to foot and mouth disease. Human VSV infections do occur, although much less frequently than in animals and with much less severe disease symptoms. This antibody binds an epitope on the VSV N protein that is different from that of antibody 1004.

Application Notes: This antibody was used for immunoprecipitation of nucleoprotein of VSV (PMID: 27573105).

Antibody first published in: Schmidt et al. Phenotypic lentivirus screens to identify functional single domain antibodies. Nat Microbiol. 2016; 1(8): 16080. PMID:27573105
Note on publication: Describes the generation of alpaca nanobodies against vesicular stomatitis virus (VSV).