Anti-PCT [PCT Nb1]

Description:

Recombinant monoclonal antibody to PCT. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody PCT Nb1.

Clone Name:

PCT Nb1

Published Application(s):

SPR, ELISA

Published Species Reactivity:

Human

Alternative Name(s) of Target: Procalcitonin
Immunogen: The original antibody was isolated by panning a camel-derived phage display nanobody library against PCT.

Specificity: The antibody is specific for PCT. PCT is a protein consisting of 116 amino acids. PCT is the peptide precursor of calcitonin, a hormone that is synthesized by the parafollicular C cells of the thyroid and involved in calcium homeostasis.

Application Notes: The specificity of the original format of the antibody was confirmed by ELISA analysis (CN104404630A). The binding affinity of the VHH fragment to PCT was measured by surface plasmon resonance (Kd= 12 nM) (Yan et al., 2015; PMID: 25944262).

Antibody first published in: Yan et al. Characterization and applications of Nanobodies against human procalcitonin selected from a novel naïve Nanobody phage display library J Nanobiotechnology. 2015 May 6;13:33. doi: 10.1186/s12951-015-0091-7. PMID:25944262
Note on publication: The paper describes the generation and characterization of the antibody by phage display selection.