Anti-Quadruplex DNA [5C10]

Description:

Recombinant monoclonal antibody to Quadruplex DNA. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 5C10.

Clone Name:

5C10

Published Application(s):

ELISA, IHC

Published Species Reactivity:

Species independent

Products based on this clone:

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Ab00393-1.1 Anti-Quadruplex DNA [5C10]
Species independent
Mouse IgG1
Purified
Ships in 4-5 weeks

Ab00393-1.4 Anti-Quadruplex DNA [5C10]
Species independent
Mouse IgG1
Fc Silent™
Purified
Ships in 4-5 weeks

Ab00393-23.0 Anti-Quadruplex DNA [5C10]
Species independent
Rabbit IgG
Purified
Ships in 4-5 weeks

Ab00393-24.1 Anti-Quadruplex DNA [5C10]
Species independent
Goat IgG
Purified
Ships in 4-5 weeks

Alternative Name(s) of Target: G4 DNA
Immunogen: Oxy-2 or d(TTTTGGGG)2

Specificity: This antibody binds to quadruplex DNA with a Kd of 24.4 nM. Binds only to the Oxy-2 type.

Application Notes: This antibody binds to quadruplex DNA, which is generated through the association of four guanines bound through Hoogsteen base pairing. G4-forming sequences are associated with immunoglobulin switch regions, promoter sequences, rDNA and telomeric repeats.

Antibody first published in: Henderson et al. Detection of G-quadruplex DNA in mammalian cells. Nucleid Acids 2014; 42(2):860-869 PMID:24163102
Note on publication: Describes the generation of several G4-DNA-specific monoclonal antibodies and how these can be used for nuclear staining.