- Ab04142-23.0 Anti-RANK-L [RL]
- Rabbit IgG
- Ships in 5-6 weeks
Recombinant monoclonal antibody to RANK-L. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody RL.
UniProt Accession Number of Target Protein: O14788
Alternative Name(s) of Target: CD254; TRANCE; RANKL; ODF; OPGL; Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; Osteoprotegerin ligand; Receptor activator of nuclear factor kappa-B ligand; TNF-related activation-induced cytokine
Immunogen: The original antibody was generated by panning a Fab library against RANKL.
Specificity: The antibody is specific for human-RANK-L. RANKL is a tumor necrosis factor (TNF)-related protein that binds to, and activates, the TNF receptor (TNFR)-related protein Receptor Activator of NF-kB (RANK). RANKL acts as the key cytokine that regulates osteoclast differentiation and activation during normal bone remodeling and during disease.
Application Notes: The origina antibody was capable of blocking the interactions between RANKL and its receptor RANK. The original antibody could potentially be used in an ELISA analysis (WO2015030701A1)
Antibody first published in: PMID: