United Kingdom (UK)
Recombinant monoclonal antibody to ROR1. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody 1G8.
UniProt Accession Number of Target Protein: Q01973
Alternative Name(s) of Target: NTRKR1; Inactive tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophic tyrosine kinase, receptor-related 1
Immunogen: A human antibody library generated from the peripheral blood lymphocytes of human donors. This specific clone was isolated by panning the library against human ROR1 protein.
Specificity: This antibody binds the human ROR1. ROR1 is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors. It is a pseudo kinase that lacks catalytic activity. Receptor tyrosine kinase ROR1 plays an essential role in embryogenesis and is overexpressed in many types of malignant tumors. Antibody-based immunotherapies targeting ROR1 have been developed and evaluated in preclinical and clinical studies with promising outcomes.
Application Notes: The original human IgG1 version of this antibody binds human ROR1 protein with a binding affinity of Kd= 4.9 nM. This antibody can be used for the detection of human ROR1 using flow cytometry (CN104817642).
Antibody first published in: PMID: