Anti-RRV E2 [D7]

Description:

Recombinant monoclonal antibody to RRV E2. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma D7.

Clone Name:

Published Application(s):

labelling, FC

Published Species Reactivity:

Ross River Virus

Products based on this clone:

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Ab00749-1.1 Anti-RRV E2 [D7]
Ross River Virus
Mouse IgG1
Purified
In Stock

Ab00749-23.0 Anti-RRV E2 [D7]
Ross River Virus
Rabbit IgG
Purified
In Stock

UniProt Accession Number of Target Protein: Q88724

Alternative Name(s) of Target: RRV Envelope gp; Ross River Virus envelope glycoprotein
Immunogen: This antibody was raised by immunizing mice.

Specificity: This antibody is specific for the E2 envelope protein of RRV.

Application Notes: This antibody binds RRV E2, and has been used to stain RRV-positive cells and in FC analysis of E2 surface expression (Jupille, 2013). This antibody has also been used to detect RRV binding to HeLa cells, demonstrating that synthetic peptides representing the α1β1 integrin binding site on collagen IV are able to inhibit RRV binding to cells, thus implicating the α1β1 integrin as an RRV cell-binding receptor (La Linn, 2005).

Antibody first published in: Jupille et al. A Tyrosine-to-Histidine Switch at Position 18 of the Ross River Virus E2 Glycoprotein Is a Determinant of Virus Fitness in Disparate Hosts Journal of Virology, 2013, Vol. 87(10), p.5970 PMID:23514884
Note on publication: Describes the use of this antibody in FC and labelling studies.