United Kingdom (UK)
Recombinant monoclonal antibody to saxiton. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 1E8.
Alternative Name(s) of Target: STX; [(3aS,4R,10aS)-10,10-dihydroxy-2,6-diiminooctahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate
Immunogen: The original antibody was generated by immunizing mice with STX-glucose oxidase immunogen.
Specificity: The antibody is specific for STX. STX is a potent neurotoxin and the best-known paralytic shellfish toxin. Ingestion of saxitoxin by humans, usually by consumption of shellfish contaminated by toxic algal blooms, is responsible for the illness known as paralytic shellfish poisoning.
Application Notes: The binding affinity of the original format of the antibody to STX was measured by surface plasmon resonance (Kd= 2.5 nM) (Shriver-Lake et al., 2017; PMID: 27879646).
Antibody first published in: Immunochemical Approaches to the Analysis of Paralytic Shellfish Poisoning Toxins PMID: Note on publication: The paper describes the generation and characterization of the antibody.