Anti-Sclerostin [3-D7]

Description:

Recombinant monoclonal antibody to Sclerostin. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the alpaca peripheral blood lymphocytes 3-D7.

Clone Name:

3-D7

Published Application(s):

ELISA

Published Species Reactivity:

Human, Mouse

UniProt Accession Number of Target Protein: Q9BQB4; Q99P68

Alternative Name(s) of Target: SOST
Immunogen: The original antibody was generated by immunizing four alpacas with recombinant human sclerostin.

Specificity: This antibody binds human and mouse sclerostin. Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain which is produced in osteocytes (type of bone cell). The glycoprotein sclerostin has been identified as a negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. Neutralizing anti-sclerostin antibodies are able to restore Wnt activity and enhance bone growth thereby presenting a new osteoanabolic therapy approach for diseases such as osteoporosis.

Application Notes: The binding reactivity of this antibody for human and mouse sclerostin was determined using ELISA (WO2010130830).

Antibody first published in: PMID: