United Kingdom (UK)
Recombinant monoclonal antibody to TIM-3. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma L3C.
UniProt Accession Number of Target Protein: Q8TDQ0
Alternative Name(s) of Target: CD366; HAVCR2; HAVcr-2; TIM3; TIMD-3; TIMD3; Hepatitis A virus cellular receptor 2; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3
Immunogen: The original antibody was generated by immunizing Balb/c mice with human TIM-3.
Specificity: This antibody binds human TIM-3. Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein expressed on the cell surface of IFNγ producing CD4+ Th1 and CD8+ Tc1 cells. This protein is also expressed on the surface of Th17 cells, regulatory T-cells and innate immune cells like dendritic cells, NK cells and monocytes. It is a cell surface receptor implicated in modulating innate and adaptive immune responses.
Application Notes: This antibody can be used in the detection of human TIM-3 from plasma of patients using sandwich ELISA. The recombinant human rhGal-9 protein was used to capture TIM-3 and this antibody was used as a detecting antibody. The detection sensitivity of this antibody for TIM-3 was 1ng/ml (CN103665164).
Antibody first published in: PMID: