Anti-Triclocarban [T9]

Description:

Recombinant monoclonal antibody to Triclocarban. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the llama peripheral blood lymphocytes T9.

Clone Name:

Published Application(s):

ELISA

Published Species Reactivity:

Species independent

Alternative Name(s) of Target: TCC; 1-(4-chlorophenyl)-3-(3;4-dichlorophenyl)urea; bactericide
Immunogen: The original antibody was generated by immunizing Llama glama intramuscularly with 600 μg of the TCC-Thy conjugate in Freund Incomplete Adjuvant.

Specificity: This antibody binds Triclocarban (TCC), which is an antibacterial chemical. This antibody also shows some cross reactivity with structurally similar compounds like 2′-OH TCC and 4,4′-Dichlorocarbanilide.

Application Notes: The binding of this antibody to triclocarban was confirmed using ELISA. SPR was used to measure the binding affinity of this antibody and it was reported to be Kd= 1.1 nM.

Antibody first published in: Rosa et al. Competitive Selection from Single Domain Antibody Libraries Allows Isolation of High-Affinity Antihapten Antibodies That Are Not Favored in the llama Immune Response. Anal Chem. 2011 Sep 15; 83(18): 7213–7220. PMID:21827167
Note on publication: Describes the isolation of high affinity nanobodies against Triclocarban.