Anti-Type IV collagenase [3G11]

Description:

Recombinant monoclonal antibody to Type IV collagenase. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 3G11.

Clone Name:

3G11

Published Application(s):

ELISA

Published Species Reactivity:

Human

5

Products based on this clone:

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Ab00421-1.1 Anti-Type IV collagenase [3G11]
Human
Mouse IgG1
Purified
In Stock

Ab00421-1.4 Anti-Type IV collagenase [3G11]
Human
Mouse IgG1
Fc Silent™
Purified
In Stock

Ab00421-10.0 Anti-Type IV collagenase [3G11]
Human
Human IgG1
Purified
Ships in 4-5 weeks

Ab00421-10.3 Anti-Type IV collagenase [3G11]
Human
Human IgG1
Fc Silent™
Purified
Ships in 4-5 weeks

Ab00421-10.7 Anti-Type IV collagenase [3G11]
Human
Human F(ab)2
AbFab2™ His-Tagged
Purified
Ships in 4-5 weeks

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UniProt Accession Number of Target Protein: P08253

Alternative Name(s) of Target: MMP2; Matrix Metalloprotease 2
Immunogen: Recombinant human type IV collagenase.

Specificity: This antibody binds specifically to human type IV collagenase and does not show any cross-reactivity with any other collagenases.

Application Notes: This antibody binds to human type IV collagenase, a metalloproteinase involved in degrading matrix proteins and hence contributing largely to metastasis in various types of cancer.

Antibody first published in: Li et al. Antitumor activity of anti-type IV collagenase monoclonal antibody and its lidamycin conjugate against colon carcinoma. World Journal of Gastroenterology 2007; 11(29):4478-4483 PMID:16052675
Note on publication: Describes the generation of a mouse monoclonal antibody against type IV collagenase in order to study possible routes towards colon carcinoma treatment.