Anti-VLP of CPV-VP2 [scFv 96]

Description:

Recombinant monoclonal antibody to VLP of CPV-VP2. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody scFv 96.

Clone Name:

scFv 96

Published Application(s):

neutralization, ELISA

Published Species Reactivity:

canine parvovirus

5

Products based on this clone:

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Ab03609-23.0 Anti-VLP of CPV-VP2 [scFv 96]
canine parvovirus
Rabbit IgG
Purified
Ships in 5-6 weeks

Ab03609-3.0 Anti-VLP of CPV-VP2 [scFv 96]
canine parvovirus
Mouse IgG2b
Purified
Ships in 5-6 weeks

Ab03609-3.3 Anti-VLP of CPV-VP2 [scFv 96]
canine parvovirus
Mouse IgG2b
Fc Silent™
Purified
Ships in 5-6 weeks

Ab03609-201.1 Anti-VLP of CPV-VP2 [scFv 96]
canine parvovirus
Dog IgG2 (IgG-B)
Purified
Ships in 5-6 weeks

Ab03609-201.4 Anti-VLP of CPV-VP2 [scFv 96]
canine parvovirus
Dog IgG2 (IgG-B)
Fc Silent™
Purified
Ships in 5-6 weeks

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UniProt Accession Number of Target Protein: P61826

Alternative Name(s) of Target: Coat protein VP2
Immunogen: This antibody was raised by first immunizing twelve-week old white Leghorn hens intramuscularly with CPV-VLP. A library was then constructed from these chickens and panned against CPV-VLP.

Specificity: This antibody is specific for the VP2 for the Canine Parvovirus. VP2 is a capsid protein that self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The Canine Parvovirus is a disease mainly affecting dogs with a 91% mortality rate.

Application Notes: To analyse the sensitivity of the scFv version of this antibody an ELISA was performed on CPV-VP2. Furthermore, the ability of this antibody to prevent a CPV infection was determined, it showed a decrease of 30% over 72 hours (Ge et al, 2020; pmid:32883344).

Antibody first published in: Ge et al. Canine Parvovirus is diagnosed and neutralized by chicken IgY-scFv generated against the virus capsid protein. Vet Res. 2020; 51: 110. PMID:32883344
Note on publication: Canine parvovirus (CPV) can cause acute and highly contagious bloody enteritis in dog. To obtain antibodies against CPV, hens were immunized with virus-like particles (VLP) of CPV-VP2. The IgY single chain fragment variables (scFv) were generated by T7 phage display system and expressed in E. coli system.