United Kingdom (UK)
Recombinant monoclonal antibody to Tumor associated glycoprotein (TAG) 72. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the therapeutic antibody B72.3 (Satumomab).
Alternative Name(s) of Target: TAG-72
Immunogen: Tumour-associated glycoprotein 72 is a glycoprotein found on the surface of many cancer cells, including ovary, breast, colon, and pancreatic cells.
Specificity: Recognises human Tumor associated glycoprotein 72.
Application Notes: A In-111-labeled, murine version of this antibody was used in immunoscintigraphy to detect colorectal cancers in patients. In 16 % of patients, human-anti-mouse-responses developed.
Antibody first published in:
Abdel-Nabi et al. In-111-labeled monoclonal antibody immunoscintigraphy in colorectal carcinoma: safety, sensitivity, and preliminary clinical results. Radiology PMID:2315476
Note on publication:
Describes the use of this antibody in detection of colorectal cancers.
Immunofluorescent staining of human rectal carcinoma using anti-TAG72 antibody Ab00280 Formaldehyde-fixed human rectal carcinoma slices were stained with Ab00280-1.1 at 5 µg/ml and detected with a Cy3-conjugated secondary antibody.
Immunohistochemical staining of human rectal carcinoma using anti-TAG72 antibody Ab00280 Formalin fixed human rectal carcinoma slices were were stained with Ab00280-1.1 at 5 µg/ml.
Immunohistochemical staining of human ovarian cancer using anti-TAG72 antibody Ab00280 Formalin fixed human ovarian cancer slices were were stained with Ab00280-1.1 at 5 µg/ml.