Fc Fusion Proteins

Fc Fusion Protein Diagram

Fc-Fusion proteins (also known as Fc chimeric fusion proteins, Fc-Ig’s, Ig-based Chimeric Fusion proteins and Fc-tag proteins) are composed of the Fc domain of IgG genetically linked to a peptide or protein of interest. Fc-Fusion proteins have become valuable reagents for in vivo and in vitro research.

Examples of Fc-fused binding partners include, but are not limited to, single peptides, ligands activated upon cell-surface receptor binding, signalling molecules, extracellular domains of a receptors activated upon dimerization and bait proteins used to identify binding partners in protein microarrays.

One of the most valuable characteristics conferred by the Fc domain in vivo is the dramatic prolonging of the plasma half-life (t1/2) of the protein of interest, which for biotherapeutic drugs can result in improved therapeutic efficacy; an attribute that has made Fc-Fusion proteins attractive biotherapeutic agents.

In vitro applications of Fc-Fusion proteins include, amongst others, immunohistochemistry (IHC), flow cytometry (FC), protein binding assays and use as microarray baits. In these applications, the Fc domain behaves as a supporting module to which proteins can be attached whilst retaining their native biological activity. The Fc domain can also improve the in vivo and in vitro solubility and stability of some binding partners.

Absolute Antibody offer a diverse array of recombinant Fc-Fusion proteins with a range of species specific and genetically engineered Fc domains such as Fc Silent™.

For further information or for bulk and custom orders do not hesitate to contact us.

Catalog NumberProduct NameRecombinant Protein SpeciesImmunoglobulin Fc domain Isotype and SpeciesIntro PriceAvailabilityProduct Page
Pr00246-10.9Recombinant human
NR3L1 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00245-10.9Recombinant human
FCRL6 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00244-10.9Recombinant human
BY55 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00243-10.9Recombinant human
TIMG2 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00242-10.9Recombinant human
TMM81 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00241-10.9Recombinant human
NCAM1 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00240-10.9Recombinant human
LINGO2 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00239-10.9Recombinant human
LAIR2 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00238-10.9Recombinant human
LAIR1 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00237-10.9Recombinant human
HAVCR1 Fc-Fusion Protein
HumanMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00236-10.9Recombinant human
CADM1 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00235-10.9Recombinant human
AMIGO3 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00234-10.9Recombinant human
CD70 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00233-1.9Recombinant mouse
4-1BB Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00232-1.28Recombinant mouse
TL1A Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00231-1.9Recombinant mouse
CD155 Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00230-1.9Recombinant mouse
CD96 Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00228-1.9Recombinant mouse
TIM-3 Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00227-1.9Recombinant mouse
TIM-1 Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00226-1.9Recombinant mouse
CD86 Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00225-1.9Recombinant mouse
CD80 Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00224-1.9Recombinant mouse
BTLA Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00223-1.9Recombinant mouse
HVEM Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00206Recombinant mouse
CD52-Fc Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00205Recombinant mouse
Fc-CD52 Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00188-10.9Recombinant human
SLAF6 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00187-10.9Recombinant human
TNR4 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00186-10.28Recombinant human
CD69 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00185-10.9Recombinant human
SEM4D Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00184-10.9Recombinant human
KLRB1 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00183-10.9Recombinant human
NKG2-F Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00182-10.9Recombinant human
TNR9 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00181-10.9Recombinant human
CEAM1 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00180-10.9Recombinant human
SLAF7 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00179-10.9Recombinant human
CD27 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00178-10.9Recombinant human
PTPRC Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00164-1.9Recombinant mouse
VISTA Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00163-1.9Recombinant mouse
TIGIT Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00162-1.9Recombinant mouse
Lag3 Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00161-1.28Recombinant mouse
CD70 Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00160-1.9Recombinant mouse
CD27 Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00159-1.28Recombinant mouse
4-1BBL Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00158-1.9Recombinant mouse
B7-H3 Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00157-1.9Recombinant mouse
ICOSL Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00156-1.9Recombinant mouse
PDL2 Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00155-1.9Recombinant mouse
CTLA4 Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00154-1.9Recombinant mouse
OX40 Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00153-1.9Recombinant mouse
ICOS Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00152-1.9Recombinant mouse
PD-1 Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00136Recombinant human
CTLA-4 Fc-Fusion Protein (Abatacept)
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
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Pr00135Recombinant human
TNFR1B Fc-Fusion Protein (Etanercept)
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00128-10.28Recombinant human
NKG2E Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00127-10.9Recombinant human
NCTR1 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00126-10.9Recombinant human
NCTR3 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00125-10.28Recombinant human
NKG2D Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00124-10.9Recombinant human
CD96 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
View Datasheet
Pr00123-10.9Recombinant human
CD226 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00122-10.9Recombinant human
TIGIT Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00117-10.9Recombinant human
EGFR Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00113-1.9Recombinant mouse
CD47 (C33 to G mutation) Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00112-1.9Recombinant mouse
PDL1 Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00111-1.9Recombinant mouse
TNFR1 Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00110-1.9Recombinant mouse
B7.1/CD80 Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In preparation,
contact us
Pr00109-1.9Recombinant mouse
IL2 Fc-Fusion Protein
MouseMouse IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In Stock
Pr00103-10.13Recombinant Human
CTLA-4 Fc Silent™-Fusion Protein
HumanHuman IgG1
Fc Silent™ mutations in the Fc
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet
Pr00103-10.9Recombinant Human
CTLA-4 Fc-Fusion Protein
HumanHuman IgG1
0.1mg for £210 / €235 / $280
1mg for £1060 / €1200 / $1440
In StockView Datasheet