Anti-Neurotoxin AahII [4C1] Standard size

Description: Recombinant monoclonal antibody to Neurotoxin AahII. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the scFv 4C1. This antibody was created using our proprietary Fc Silent™ engineered Fc domain containing key point mutations that abrogate binding to Fc gamma receptors.
Isotype and Format: Mouse IgG1, Fc Silent™, kappa
Clone Number: 4C1
Published Application(s): ELISA; NTRL
Published Species Reactivity: Androctonus australis hector
Immunogen: C-terminus of AahII
Specificity: This scFv binds specifically to the C-terminal region of the toxin.
Application Notes: This scFv binds to the C-terminus of the neurotoxin AahII, which binds and blocks sodium channels in a voltage-independent manner. The antibody neutralizes the toxin.
Antibody First Published in:
Mousli et al. 1999 FEBS Letters 1999; 442(2-3):183-188 PMID:9928998 Note on publication: Describes the engineering of an scFv that, similar to the whole antibody, neutralizes the activity of the neurotoxin.

Product Form

This is a Standard size product. Purified antibody.
Purification: Protein A affinity purified
Supplied in: PBS with 0.02% Proclin 300.
Storage Recommendation: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
Concentration: See vial label

Product Code: Ab00366-1.4

Mouse IgG1

Ships in 4-6 weeks
Standard size 200 µg
Custom conjugation:
Clear selection
Ships in 4-6 weeks
Bulk size
1 mg