Anti-IL-2 [S4B6] Standard size

Description: Recombinant monoclonal antibody to IL-2. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma S4B6. This antibody was created using our proprietary Fc Silent™ engineered Fc domain containing key point mutations that abrogate binding to Fc gamma receptors.
Isotype and Format: Mouse IgG1, Fc Silent™, kappa
Clone Number: S4B6
Published Application(s): ELISA; SPR; Blocking
Published Species Reactivity: Mouse
Immunogen: Interleukin-2.
Specificity: This antibody binds specifically to mouse IL-2.
Application Notes: This antibody binds to Interleukin-2, a protein produced by T-cells in response to antigenic or mitogenic stimulation. It triggers T-cell proliferation and can stimulate B-cells, monocytes, natural killer cells and glioma cells. The antibody blocks the Il-2:IL-2R-beta interaction.
Antibody First Published in:
Spangler et al. Immunity 2015; 42(5):815-8125 PMID:25992858 Note on publication: Describes the generation of two monoclonals against mouse IL-2 and subsequent blocking studies.

Product Form

This is a Standard size product. Purified antibody.
Purification: Protein A affinity purified
Supplied in: PBS with 0.02% Proclin 300.
Storage Recommendation: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
Concentration: See vial label

Product Code: Ab00440-1.4

Mouse IgG1

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Standard size 200 µg
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