United Kingdom (UK)
Recombinant monoclonal antibody to PfRH5. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 9AD4.
UniProt Accession Number of Target Protein: B2L3N7
Alternative Name(s) of Target: P. falciparum RH5; Plasmodium falciparum Reticulocyte-binding Protein Homologue 5
Immunogen: Human adenovirus serotype 5 (AdHu5).
Application Notes: The antibody binds specifically to PfRH5, a member of the RH family of proteins of the Plasmodium falciparum which interacts with the surface protein basigin (CD147) of erythrocytes. The interaction between the two proteins is necessary for the parasitic invasion of erythrocytes, known to give rise to the pathology of malaria. The antibody 9AD4 inhibits parasitic growth, possibly by blocking the interaction of PfRH5 and another protein, or by blocking the processing of the PfRH5 protein.
Antibody first published in:
Wright et al. Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies. Nature 515 (7527), 427-430 (2014) PMID:25132548
Note on publication:
Describes the role of the reticulocyte-binding protein homologue family of proteins found in Plasmodium falciparum, of which RH5 is necessary for erythrocyte invasion. This is essential to the life cycle of the parasite, and is responsible for the development of malaria. Antibodies against PfRH5, such as 9AD4 and QA1, prevent parasite growth and have the potential to be used therapeutically in malaria vaccines.