Anti-E-protein DIII (C-C') [ZV-64] Standard size

Description: Recombinant monoclonal antibody to E-protein DIII (C-C'). Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma ZV-64.
Isotype and Format: Human IgM, kappa
Clone Number: ZV-64
Published Application(s): NTRL; crystallization; SPR; FC
Published Species Reactivity: Zika Virus
Immunogen: This antibody was generated by infecting mice with 1000 FFU of ZIKV MR-766 followed by a booster at 30d post-infection of ZIKV H/PF/2013, respectively and given a final intravenous boost with live ZIKV DIII (amino acids 299 to 407 of the ZIKV E protein))
Specificity: ZV-64 binds to the Zika virus envelope protein at domain III (DIII, C-C’ loop). No cross-reactivity with other tested flaviviruses has been reported.
Application Notes: The original mouse IgG2c format has been shown to have neutralizing activity and has been used to label ZIKV infected cells (4% PFA fixation, 0.1% saponin permeabilization).
Antibody First Published in:
Zhao et al. Cell. 2016 Aug 11;166(4):1016-27 PMID:27475895 Note on publication: Describes the generation and characterisation of this antibody.

Product Form

This is a Standard size product. Purified antibody.
Purification: Affinity Purified using a recombinant lectin column
Supplied in: PBS with 0.02% Proclin 300.
Storage Recommendation: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
Concentration: See vial label

Product Code: Ab00811-15.0

Human IgM

Ships in 2-3 weeks
Bulk size
500 µg