Approaching Bispecific Antibody Engineering

Bispecific antibodies are an increasingly important class of therapeutics with applications ranging from oncology to infectious disease. Designing bispecific antibodies is a complex process, enabling drug developers additional levels of optimization and fine-tuning of lead compounds. Though the task may be daunting, some common challenges of generating bispecific antibodies have been tackled by protein engineers with creative approaches.

This presentation covers suggested initial go-to formats for bispecific antibodies and the rationale behind starting off bispecific antibody campaigns with such formats. The utility of mouse bispecific antibodies in basic research and drug discovery will also be discussed, including specific examples of their use.

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