United Kingdom (UK)
Recombinant monoclonal antibody to Ampicillin. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody aL2.
Alternative Name(s) of Target: Principen; AM; AMP
Immunogen: The original antibody was generated through the construction of a phage-displayed scFv library from Balb/c mice immunized with an ampicillin-bovine serum albumin conjugate.
Specificity: This antibody is specific for intact ampicillin.
Application Notes: This antibody was screened using ELISA, and its crystal structure has been determined (Burmester et al., 2001; PMID: 11397088).
Antibody first published in:
Burmester et al. Selection, characterization, and x-ray structure of anti-ampicillin single-chain Fv fragments from phage-displayed murine antibody libraries J Mol Biol. 2001 Jun 8;309(3):671-85. doi: 10.1006/jmbi.2001.4663 PMID:11397088
Note on publication:
The original publication investigates the construction of single-chain Fv (scFv) antibody libraries from mice immunized with an ampicillin-bovine serum albumin conjugate, leading to the selection, characterization, and X-ray structure determination of an anti-ampicillin scFv fragment (aL2) with specificity for intact ampicillin.