United Kingdom (UK)
Recombinant monoclonal antibody to CD226. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma DN12.
UniProt Accession Number of Target Protein: Q15762
Alternative Name(s) of Target: DNAM1; DNAM-1; TLisA1; PTA-1; CD226 antigen; DNAX accessory molecule 1; T lineage specific activation antigen 1; platelet and T cell antigen 1
Immunogen: The original antibody was generated by immunizing 4-6 weeks old female SPF or BALB/c mice with human DNAM-1 commercial antigen.
Specificity: This antibody binds human CD226. This protein is expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. It is involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. It acts as cell surface receptor for NECTIN2. On binding with ligand it stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG.
Application Notes: The binding characterization of this antibody to human CD226 was done using ELISA. This antibody was used for the detection of CD226 expressed on Jurkat cells using flow cytometry (CN112940122).
Antibody first published in: PMID: