United Kingdom (UK)
Recombinant monoclonal antibody to CD226. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma FMU-mCD226.1.
UniProt Accession Number of Target Protein: Q8K4F0
Alternative Name(s) of Target: DNAM1; DNAM-1; TLisA1; PTA-1; CD226 antigen; DNAX accessory molecule 1; T lineage specific activation antigen 1; platelet and T cell antigen 1
Immunogen: The original antibody was generated by immunizing CD226KO (CD226 knockout) mice with purified CD226-Fc recombinant fusion protein.
Specificity: This antibody binds mouse CD226. This protein is expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. It is involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. It acts as cell surface receptor for NECTIN2. On binding with ligand it stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG.
Application Notes: The binding of this antibody to recombinant mouse CD226-Fc fusion protein was determined using indirect ELISA. This antibody is capable of binding mouse CD226 expressed on wild-type mouse platelets in a flow cytometric assay. This antibody was also reported to promote platelet aggregation. This antibody can be used to identify CD226 expressed in platelet lysates using western blot (CN111363042).
Antibody first published in: PMID: