United Kingdom (UK)
Recombinant monoclonal antibody to CD38. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 13B5B11C8.
UniProt Accession Number of Target Protein: P28907
Alternative Name(s) of Target: CGMCC NO.22319; ADP-ribosyl cyclase/cyclic; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; 38C03
Immunogen: The original antibody was generated by immunizing BALB/c mice with CD38.
Specificity: The antibody is specific for CD38. CD38 is a single-chain transmembrane type II glycoprotein with a molecular weight of 45kD, including a long carboxyl-terminal extracellular domain (258 amino acids), a transmembrane domain (21 amino acids) and a short amino-terminal Intracellular region (21 amino acids). CD38 is a multifunctional protein with receptor and enzyme-mediated functions, which can act as receptor, adhesion molecule and exonuclease.
Application Notes: The antibody specifically detected CD38 by Western blot analysis. The antibody 13B5B11C8 and the commercial antibody 38C03 were used to stain B-cell lymphoma and T-cell lymphoma. Results showed the antibody specificity is comparable to the commercial antibody. Further, the sensitivity of the antibody 13B5B11C8 was higher than the commercial antibody. The antibody and the commercially available antibody 38C03 were simultaneously detected on the normal tissue chip, indicating that the specificity of the antibody in normal tissue was equivalent to that of the commercially available antibody (CN113912727A).
Antibody first published in: PMID: