United Kingdom (UK)
Recombinant monoclonal antibody to CD56. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma RNL-1.
UniProt Accession Number of Target Protein: P13591
Alternative Name(s) of Target: N-CAM; N-CAM-1; NCAM-1; Neuronal Cell Adhesion Molecule; Neural cell adhesion molecule 1
Immunogen: The original antibody was generated by using a NCI-H82 cell preparation as an immunogen.
Specificity: The antibody is specific for CD56.
Application Notes: The original antibody stained CD56 in NCI-H82 cells (Broers et al., 1991; PMID: 1845952). The antibody was reactive with SCLC, lung carcinoids, renal cancers, and some sarcomas. The antibody was reactive in normal neuronal tissues, and endocrine glands, such as pancreatic islet cells, pituitary gland, and adrenal medulla. The antibody reacted positively in the immunofluorescence assay with the NCAM-transfected 3T3 cells (Boerman et al., 1991; PMID: 1645701). The antibody was used to detect CD56 on SCLC cell lines by immunohistochemistry (Borghtet al., 2018; PMID: 30050775).
Antibody first published in:
Broers et al. Novel antigens characteristic of neuroendocrine malignancies Cancer. 1991 Feb 1;67(3):619-33. PMID:1845952
Note on publication:
The original paper describes the generation and characterization of the antibody.