Anti-Cytokeratin 8 [14C2]

Description:

Recombinant monoclonal antibody to Cytokeratin 8. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 14C2.

Clone Name:

14C2

Published Application(s):

ELISA, IHC

Published Species Reactivity:

Human

Products based on this clone:

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Ab03178-23.0 Anti-Cytokeratin 8 [14C2]
Human
Rabbit IgG
Purified
Ships in 4-5 weeks

Ab03178-1.1 Anti-Cytokeratin 8 [14C2]
Human
Mouse IgG1
Purified
In Stock

Ab03178-5.0 Anti-Cytokeratin 8 [14C2]
Human
Mouse IgG3
Purified
Ships in 4-5 weeks

Ab03178-10.0 Anti-Cytokeratin 8 [14C2]
Human
Human IgG1
Purified
Ships in 4-5 weeks

UniProt Accession Number of Target Protein: P05787

Alternative Name(s) of Target: CK8; CK-8; CK 8; KRT8; CYK8; Keratin type II cytoskeletal 8; Cytokeratin-8; Type-II keratin Kb8; CGMCC NO 20769; TS1
Immunogen: The original antibody was generated by immunizing ICR mice with a recombinant polypeptide comprising human cytokeratin 8 cross linked to bovine serum albumin and KLH carrier protein.

Specificity: This antibody binds human cytokeratin 8. Cytokeratins are intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. Together with KRT19, cytokeratin 8 helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

Application Notes: This antibody can recognize human cytokeratin 8 in an ELISA. The affinity constant for the original IgG3 antibody was calculated to be 9.6 × 10^(8) M^(-1). This antibody was used in the immunohistochemical analysis of breast cancer, liver bile duct epithelial cells and adenocarcinoma tissues (CN112940118).

Antibody first published in: PMID:

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