United Kingdom (UK)
Recombinant monoclonal antibody to GXM. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 2H1.
Alternative Name(s) of Target: Glucuronoxylomannan; Cryptococcus neoformans capsular polysaccharide; CNPS
Immunogen: The original mouse version of this antibody was raised by infecting balb/c mice with C. neoformans and then immunizing them with glucuronoxylomannan-tetanus toxoid conjugate (GXM-TT).
Specificity: This antibody is specific for GXM from C.neoformans. GXM is a polysacharide experssed on the surface of c.neoformans.
Application Notes: To characterize the mouse version of this antibody an ELISA was performed on native and de-O-acetylated serotype A GMX using the mouse version of this antibody (Casadevall et al, 1992; pmid:1583327). In research on the efficacy of the mouse version of this antibody against diverse strains of Cryptococcus neoformans. This antibody showed the ability to reduce the amount of yeast cells present in the organs of mice (Mukherjee et al, 1995; pmid:7642262).
Antibody first published in:
Casadevall et al. Antibodies elicited by a Cryptococcus neoformans-tetanus toxoid conjugate vaccine have the same specificity as those elicited in infection J Infect Dis. 1992 Jun;165(6):1086-93. PMID:1583327
Note on publication:
The antibody responses of BALB/c mice to serotype A Cryptococcus neoformans capsular polysaccharide (CNPS) were compared after cryptococcal infection and immunization with a serotype A glucuronoxylomannan-tetanus toxoid conjugate.