Anti-Herpes simplex virus [H85]

Name: Anti-Herpes simplex virus [H85]
SKU: Ab03694
Availability: InStock

Description:

Recombinant monoclonal antibody to Herpes simplex virus. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody H85.

Clone Name:

H85

Published Application(s):

ELISA, IF

Published Species Reactivity:

Herpes Simplex Virus

Product based on this clone:

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Ab03694-23.0 Anti-Herpes simplex virus [H85]
Herpes Simplex Virus
Rabbit IgG
Purified
Ships in 5-6 weeks

Alternative Name(s) of Target: HSV
Immunogen: The Fab fragment was selected from a human combinatorial antibody library constructed in a phage-display vector by a panning procedure against an HSV lysate.

Specificity: The antibody binds to herpes simplex virus (HSV) antigens. The antibody is reactive with HSV-1 only.

Application Notes: The specificity of the original format of the antibody was confirmed by ELISA analysis. The Fab was able to specifically recognize Vero cells infected by HSV-1 in indirect immunofluorescence (IF) assays. The Fab was further evaluated as reagents for viral detection and typing by IF staining in 134 HSV-positive (72 HSV-1 and 62 HSV-2) viral cultures from clinical specimens, where it recognized the F (HSV-1) reference strain . The detection sensitivity with the Fab in indirect IF assays was higher overall than that provided by the type-specific murine monoclonal antibodies (Cattani et al., 1997; PMID:9163470).

Antibody first published in: Cattani et al. Detection and typing of herpes simplex viruses by using recombinant immunoglobulin fragments produced in bacteria J Clin Microbiol. 1997 Jun;35(6):1504-9. PMID:9163470
Note on publication: The original paper describes the generation and characterization of the antibody.

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