Anti-IL-17A [1G8]

Name: Anti-IL-17A [1G8]
SKU: Ab02599
Availability: InStock

Description:

Recombinant monoclonal antibody to IL-17A. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybrodoma 1G8.

Clone Name:

1G8

Published Application(s):

WB, ELISA, FC

Published Species Reactivity:

Chicken

Products based on this clone:

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Ab02599-1.1 Anti-IL-17A [1G8]
Chicken
Mouse IgG1
Purified
Ships in 5-6 weeks

Ab02599-23.0 Anti-IL-17A [1G8]
Chicken
Rabbit IgG
Purified
Ships in 5-6 weeks

UniProt Accession Number of Target Protein: B4ER12

Alternative Name(s) of Target: Interleukin 17A; chIL-17; Interleukin-17A; IL-17; chicken IL-17A
Immunogen: The original antibody was raised by immunizing BALB/C mice with recombinant chicken IL-17.

Specificity: The antibody binds specifically to chicken IL-17, a proinflammatory cytokine produced by activated T cells. Further, The antibody binds to duck IL-17.

Application Notes: The specificity of this antibody (IgG1) was confirmed in ELISA analysis. The antibody detected the recombinant chIL-17A by western blot. This antibody was used for flow cytometry on CU205 cells (Yoo et al, 2008; pmid: 18022248). The antibody was used to study the interactions between chIL-17RA and chIL-17A by western blot (Kim et al, 2014; pmid: 24980970). The cross-reactivity of the antibody to chIL17 with duck IL17 was evaluated by indirect ELISA. The binding intensity of the antibody to recombinant chIL17 was similar to recombinant duIL17. The antibody detected duIL-17A by western blot (Yoo et al., 2009; pmid: 19573930).

Antibody first published in: Yoo et al. Monoclonal antibodies reactive with chicken interleukin‐17. Vet Immunol Immunopathol. 2008;121(3‐4):359 ‐363. PMID:18022248
Note on publication: The article describes the generation and characterization of the antibody.

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