Anti-IL-2 [UFKA-20]

Name: Anti-IL-2 [UFKA-20]
SKU: Ab02947
Availability: InStock

Description:

Recombinant monoclonal antibody to IL-2. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma UFKA-20.

Clone Name:

UFKA-20

Published Application(s):

ELISA, FC

Published Species Reactivity:

Human

Products based on this clone:

Product
Species Reactivity
Isotype/Format
Modification
Formulation
Availability

Please Select

Ab02947-10.0 Anti-IL-2 [UFKA-20]
Human
Human IgG1
Purified
Ships in 5-6 weeks

Ab02947-10.3 Anti-IL-2 [UFKA-20]
Human
Human IgG1
Fc Silent™
Purified
Ships in 5-6 weeks

Ab02947-3.0 Anti-IL-2 [UFKA-20]
Human
Mouse IgG2b
Purified
Ships in 5-6 weeks

Ab02947-3.3 Anti-IL-2 [UFKA-20]
Human
Mouse IgG2b
Fc Silent™
Purified
Ships in 5-6 weeks

UniProt Accession Number of Target Protein: P60568

Alternative Name(s) of Target: IL2; IL-2; TCGF; Interleukin-2; T-cell growth factor; Aldesleukin
Immunogen: The original antibody was generated immunizing Balb/c mice with human IL-2.

Specificity: This antibody binds human IL-2. In particular, the antibody binds IL-2 dorsolaterally, with an angle of 55° counterclockwise to the vertical axis, contacting the C- and B-helices of IL-2 and thereby forming a “clamp” around the C-helix. The antibody engages IL-2 residues D84, N88, V91, E61, E68, and K64.

Application Notes: This antibody binds to Interleukin-2, a protein produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/UFKA-20 complex shows an improved selectivity towards regulatory T cells compared to IL-2 alone. IL-2/UFKA-20 can recognize the receptor IL of regulatory T cells on the base of the presence of CD25, therefore called CD25 bias. IL-2/UFKA-20 complex is able to efficiently stimulate CD25+ Treg cells in mice and rhesus macaques in vivo as well as in humans ex vivo.

Antibody first published in: Karakus et al. Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species. Sci Transl Med. 2020 Dec 16;12(574):eabb9283. PMID:33328333
Note on publication: The authors identified a anti-human IL-2 antibody which was particularly efficient in delivering IL-2 to cells expressing trimeric IL-2Rs. Further IL-2/UFKA-20 complex, crystal structure, mechanism of action are described.

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