Anti-IQGAP2 [A2]

Name: Anti-IQGAP2 [A2]
SKU: Ab02625
Availability: InStock

Description:

Recombinant monoclonal antibody to IQGAP2. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma A2.

Clone Name:

Published Application(s):

Published Species Reactivity:

Human, Mouse

Products based on this clone:

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Ab02625-2.0 Anti-IQGAP2 [A2]
Human, Mouse
Mouse IgG2a
Purified
In Stock

Ab02625-2.3 Anti-IQGAP2 [A2]
Human, Mouse
Mouse IgG2a
Fc Silent™
Purified
Ships in 4-5 weeks

Ab02625-10.0 Anti-IQGAP2 [A2]
Human, Mouse
Human IgG1
Purified
Ships in 4-5 weeks

Ab02625-10.3 Anti-IQGAP2 [A2]
Human, Mouse
Human IgG1
Fc Silent™
Purified
Ships in 4-5 weeks

Ab02625-23.0 Anti-IQGAP2 [A2]
Human, Mouse
Rabbit IgG
Purified
In Stock

UniProt Accession Number of Target Protein: Q13576

Alternative Name(s) of Target: Ras GTPase-activating-like protein IQGAP2
Immunogen: The original mouse version of this antibody was raised by immunizing A/J mice with his-tagged human IQGAP2.

Specificity: This antibody is specific for human and murine IQGAP2. IQGAP2 binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

Application Notes: Aliquots of chronically infected or uninfected N2a cells were used for immunofluorescence with the mouse version of this antibody. This was done to research genes associated with prion propagation (Marbiah et al, 2014; pmid:24843046).

Antibody first published in: Marbiah et al. Identification of a gene regulatory network associated with prion replication EMBO J. 2014 Jul 17;33(14):1527-47. PMID:24843046
Note on publication: A gene regulatory network associated with prion propagation at the ECM and governed by the cellular differentiation state was indentified.

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