United Kingdom (UK)
Recombinant monoclonal antibody to LRP4 (cytoplasmic). Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma N164/6.1.
UniProt Accession Number of Target Protein: Q8VI56
Alternative Name(s) of Target: N164/6.1R; N164/6; Low-density lipoprotein receptor-related protein 4; LRP-4; LDLR dan
Immunogen: This antibody was raised by immunising BALB/c mice with a fusion protein amino acids 1747-1905 (cytoplasmic C-terminus) of mouse LRP4.
Specificity: This antibody is specific for the LRP4 protein. LRP4 mediates SOST-dependent inhibition of bone formation.
Application Notes: This antibody is recommended for the detection and analysis of LRP4 by immunocytochemistry and western blot. For instance, the mouse version of this antibody was used to detect LRP4 by western blot in extract of adult rat brain membrane.
Antibody first published in:
Andrews et al. A toolbox of IgG subclass-switched recombinant monoclonal antibodies for enhanced multiplex immunolabeling of brain eLife. 2019; 8: e43322. PMID:30667360
Note on publication:
This article describes the generation of a library of recombinant monoclonal antibodies (R-mAbs) from a pool of mAb-producing hybridomas for neuroscience research.