United Kingdom (UK)
Recombinant monoclonal antibody to Latent TGF-beta1. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 2F10.
UniProt Accession Number of Target Protein: Q14766
Alternative Name(s) of Target: LAP; latent TGF-β1; Transforming growth factor beta-1-binding protein 1; LTBP-1; Latent-transforming growth factor beta-binding protein 1; TGF-beta1-BP-1
Immunogen: The original antibody was raised by immunizing mice with evolutionally conserved unique sequences (10 amino acids) located in LAP and mature TGF-βΙ regions of latent TGF-βΙ polypeptide.
Specificity: This antibody is specific for an evolutionally conserved unique sequence (10 amino acids) located in LAP and mature TGF-β1 regions of latent TGF-β1 polypeptide.
Application Notes: Immunohistochemistry was performed against a cancer tissue array (including 6 HCC clones, 6 choiangiocarcinoma clones, 6 lung adenocarcinoma clones, 6 RCC clones, 5 breast cancer clones, 6 ovarian cancer clones, 2 cervix cancer clones) using this antibody (WO2018235964). Immunofluorescense was performed against a HepG2 cells using this antibody (WO2018235964). ELISA with this antibody was performed on antigen peptide and TGF- i (WO2018235964). This antibody was also used for immunostaining on colorectal cancer tissues (WO2019045086).
Antibody first published in: Yukikazu et al. Anti-tgf-beta1 antibodies. WO2018235964 PMID: